Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression
نویسندگان
چکیده
Biochemical and genetic mechanisms of oxidative stress (OS) developing in blood patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty T2DM 10 healthy persons participated this study. Lipid peroxidation, the content protein carbonyls H2O2 production measured plasma erythrocytes as OS biomarkers. Activity SOD, catalase, GPx well reduced glutathionе (GSH) level estimated. The gene expression key regulators oxygen metabolic homeostasis (HIF-1α mTOR) leukocytes was It found a significant rise TBARS from compared to control. diabetic also demonstrated an increase SOD catalase activity significantly lower GSH participants. established marked inhibition mTOR tendency HIF-1α may serve protective mechanism which counteracts cell damage. Keywords: HIF-1α, mTOR, stress, diabetes
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ژورنال
عنوان ژورنال: Ukrainian Biochemical Journal
سال: 2023
ISSN: ['2409-4943', '2413-5003']
DOI: https://doi.org/10.15407/ubj95.02.048